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Although comparative studies have showed that Hunner lesions patients are older, 86, 87, 101-103 have greater urinary frequency and nocturia, 86, 87, 102, 103 higher ICSI scores, 86, 87, 103 and lower bladder capacity 101, 103 compared to those without Hunner lesion, cystoscopy remains the only reliable way to diagnose the presence or absence of Hunner lesions given the overlaps in clinical symptomatology

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In general mB12/LDFA has a significant influence on redox regulation with medium effect sizes, particularly in the role of positively affecting glutathione metabolism and its precursors, whereas BH4 primarily has a positive effect on markers of oxidative damage as well as methylation metabolism with large effect sizes