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2) Nonoxidative steps of pentose phosphate shunt transketolase requires thiamine pyrophosphate (vitamin B1) transketolase requires thiamine pyrophosphate (vitamin B1) Positive regulator of lipid synthesis GSSG is oxidized and GSH is reduced glutathione

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These mechanisms include the activation of the zinc finger transcription factor CREB-mediated IL-6/STAT3/cyclin D1 pathway, the overexpression of neuropilin-1 (NRP-1), vascular endothelial growth factor (VEGF), and matrix metalloproteases (MMP-2 and MMP-9), repression of zona occludens-1 (ZO-1) and claudin-1 by zinc finger E-box binding homeobox 1 (ZEB1), and RAB27B-mediated release of extracellular vesicles from cancer cells 8183 ( Figure 3C )