glutathione trisulfide showing a 28% increase in cellular glutathione levels after just two weeks Reactive Sulfur Species | Arteriosclerosis,

While oral glutathione is generally considered to be safe, there is not enough data to recommend long-term use, especially for women who are pregnant or breastfeeding, people who take prescription or over-the-counter drugs, and those who have chronic conditions, says Malhotra

Progressive depletion of cellular glutathione can also be used as a mechanism by some viruses to control their replication cycle.

Such depletion can be due to reduction of GSH due to excessive NAPQI exposure and/or to GSH depletion associated with elevated dopamine secondary to dopamine -hydroxylase inhibition by phenolic Clostridia metabolites

Rhonda Patrick: I actually think that it's almost impossible