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More widespread use of available tools and development of new tools that discriminate between pore, leak, and unrestricted pathway permeabilities and underlying regulatory mechanisms will be essential to understanding the local and systemic consequences of intestinal barrier loss.

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Despite the availability of modern and effective vaccines and the optimization of therapeutic protocols, IMD, with its most frequent manifestations, sepsis and meningitis, continues to claim victims and to represent a major public health problem

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Formation of oxygen radicals in biological systems There are many and various types of free radicals in biological systems, however, those derived from oxygen, generally termed reactive oxygen species (ROS) are of major concern and interest to researchers in the field of free radical chemistry

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