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Description

The dyschromia presents with depigmented macules, due to loss of melanocytes from the cutaneous epidermis or loss of the ability to secrete melanin

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The synthetic analogue of -MSH, Afamelanotide (also called Melanotan I), in association with phototherapy, demonstrated some positive effects due to its capacity to promote melanocyte proliferation and pigment production [94]

The vessels are most often comma-like/peripheral but can be hairpin or arborising, which may result in confusion with basal cell carcinoma

MC3R / Hypothalamic and Peripheral Modulation PT-141 engages MC3R expressed in hypothalamic neurons, brainstem nuclei, and peripheral immune and metabolic tissues