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Glutathione in the treatment of liver diseases: insights from clinical practice states, Judging on the basis of the evidence obtained from experimental research and previous clinical studies, GSH administration seems to be a promising strategy to recover oxidative stress-induced liver damages in alcoholic and non-alcoholic liver diseases. Glutathione supplementation is a critical part of a two-pronged approach to help the liver stay healthy and combat alcohol damage, which includes: Lifestyle choices: Limit alcohol and other toxins that you can control, like tobacco, as well as environmental stressors like pesticides and excessive UV rays

GSH has many different roles, including protection against reactive oxygen species and the maintenance of protein thiol groups

For instance, the HCD model effectively induces hepatic cholesterol deposition and inflammation, making it suitable for studying the progression to steatohepatitis (NASH) and fibrosis (Ma et al., 2019)