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Supplementary material The Supplementary Material for this article can be found online at: Glossary ALB albumin, Anpep: alanyl-aminopeptidase AOD average optical density (IOD area) CREA creatinine CKD chronic kidney disease CUR curtain gas Cys-Gly l-cysteine-l-glycine DAB 3,3-diaminobenzidine ER estrogen receptor alpha ER estrogen receptor beta ESI electron spray ionization GABA gamma-aminobutyric acid GAPDH glyceraldehyde 3-phosphate dehydrogenase Ggt1 gamma-glutamyltransferase 1 GLU glucose GO Gene Ontology GSH-Px glutathione peroxidase GSH/GSSG ratio reduced/oxidized glutathione ratio H&E hematoxylin and eosin HPL Hypericum perforatum L

15 ROS include radical compounds, such as superoxide, hydroxyl radicals, and lipid hydroperoxides, and reactive nonradical compounds, such as singlet oxygen, hydrogen peroxide (H 2 O 2 ), hypochlorous acid, chloramines, and ozone

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