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Puking while passed out Unresponsive to normal attempts to wake Breathing is slow, noisy, shallow or has stopped Skin is blue, cold or clammy See even one sign

The commonly referenced therapeutic range of 0.25-0.5 mg daily (250-500 mcg) extrapolates from the effective rat dose of approximately 10 mcg/kg body weight

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Hydroxocobalamin , the most commonly used form in the UK, has a significantly longer duration of action compared to cyanocobalamin