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10.1006/bbrc.2001.6170 43 KaidoT.OeH.YoshikawaA.OkajimaA.ImamuraM

Tumor necrosis factor (TNF) is a core inflammatory factor in RA, which inhibits phosphatase and tensin homologue-induced kinase 1 (PINK1)-mediated mitophagy and elicits mitochondrial damage, which increases cytoplasmic mtDNA levels and activates cGAS-STING, boosting inflammation in RA (105) (Figure 2)