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Conversely, smaller studies exploring acute, peri-procedural administration, such as intravenous Vitamin C combined with E pre-PCI [PREVEC trial (Rodrigo et al., 2014)] or intracoronary Vitamin E during surgery (Canbaz et al., 2003), showed some positive signals regarding reduced infarct size or injury markers, underscoring the importance of timing and local delivery

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Consequently, its not surprising that in a study investigating the status of different vitamins in elderly population and the effect of vitamin supplements on their health, it was found that 88% of subjects were deficient in vitamin D while 42% were deficient in vitamin K [147], and justifying the importance of regular vitamin intake in this age to avoid many complication that could result from vitamin deficiency or overdoses [147]