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Front Pharmacol (2020) 11:515

Michels J, Venkatesh D, Liu C, Budhu S, Zhong H, George MM, et al

Perrotta and Aquila, 2015)

Although the pathological mechanisms leading to ALS are still unknown, a wealth of evidence indicates that an excessive reactive oxygen species (ROS) production associated with an inefficient antioxidant defense represents an important pathological feature in ALS