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For each included study, the following information was collected: first authors name, year of publication, country of origin, type of study (in vitro, in vivo, or clinical), characteristics of the experimental model (e.g., species, sample size), specific platelet-derived product used (PRP, PRGF, PRF, or PRPL), details of preparation protocols, route and frequency of administration, and main outcome measures

For 13 C-labeled metabolites, we retrieved their metabolic reaction relationship from metabolic reaction network curated using the KEGG database, which results in reaction pairs (RPs) between labeled metabolites (Fig