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Inhibition of activities of the cystine/glutamate transporter system decreases cystine absorption, thereby reducing GSH synthesis, followed by decreased membrane lipid repair enzyme GPX4 activities, reduced antioxidant capacities and ferroptosis ( Chemotherapy is the preferred therapeutic option for cancer, however, long-term chemotherapy leads to increased tumor cell resistance ( 2 Ferroptosis mechanisms Studies are increasingly aimed at elucidating the mechanisms of ferroptosis

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