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C6 cells were transfected at 80% confluence with a combination of GluN1 and GluN2A or GluN2B (3.75 g cDNA/wells) + 10 l of Lipofectamine (Invitrogen) diluted in Opti-MEM TM (Gibco TM )

Results indicate that DJX-A-KM effectively degrades KRAS G12C in NCI-H23 and MIA PaCA-2 tumors in vivo, thereby inhibiting tumor growth in both models (Fig