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Collectively, we have shown using both a small animal rat model and a large animal cynomolgus monkey model that fibroblast therapy can be used to maintain the IVD height and the biomechanical properties of degenerative IVDs

This mixture was incubated in the dark for 2 to 4 hours at room temperature

Therefore, results cannot be explained by light affecting depressive-like behavior through other pathways [i.e., without disturbing sleep or circadian rhythmicity, or through pathways unrelated to the SCN ( Clinical evidence supports that dysfunctions of the circadian timekeeping system are present in a variety of morbid clinical conditions, such as obesity, diabetes, hypercholesterolemia, cardiovascular diseases, and cancer (Figure 1)

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