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Literature suggests little if no correlation between rheumatic disease and COVID-19 disease severity in hospitalized patients ( Further evidence indicates that patients with SLE test positive for COVID-19 at lower rates than individuals with other autoimmune diseases such as Sjgrens syndrome (SS) and systemic sclerosis (SSc) ( While more research is needed to reach a consensus on the relative risk of severe COVID-19 in individuals with SLE, evidence of abnormal clotting in some COVID-19 cases may implicate additional considerations for clinical care of COVID-19 patients who have SLE

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The transcriptomic divergence could simply reflect the difference between acute chemical shock and steady-state adaptation