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Studies have also demonstrated that renal cortical structure damage induced by limb ischemia-reperfusion injury can be ameliorated by ALA [80] and ALA, and when combined with the xanthine oxidase inhibitor febuxostat, shows superior protective effects on renal ischemia reperfusion injury [81]

2.1.4 Impaired intestinal and renal excretion Approximately 90% of patients with gout exhibit impaired uric acid excretion, primarily due to reduced renal urate clearance (Nakayama et al., 2023

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

The model assumes that the electrons and factors mediating reductive processes, such as reductase enzymes, are abundant and that doxorubicin reduction occurs readily