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The forces involved in squirting a liquid directly onto the powder or, even worse, shaking the vial vigorously can be enough to shear those delicate peptide bonds apart

Nat Cell Biol 26(8):12871295 Wu LK, Agarwal S, Kuo CH, Kung YL, Day CH, Lin PY et al (2022) Artemisia leaf extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinsons disease