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Review Genetic causes of growth hormone insensitivity beyond GHR.[Rev Endocr Metab Disord

Or is it to do with the sheer amount of work B12 has to do in the body

Tryptophan prototrophy inhibits V-ATPase-dependent autophagy Because nitrogen starvation and V-ATPase dysfunction represent two different types of stress, we reasoned that in addition to the Gcn2-Gcn4 pathway shared by both scenarios, V-ATPase-dependent autophagy must have some unique aspects to its regulatory mechanisms