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Acknowledgments We would like to thank Jianhui Wang for his excellent experimental techniques and other members of the AC laboratory for helpful discussion and technical support

leads to pancreatic islet cell damage, whereas the db/db mouse model is deficient in leptin receptors

History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy