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The results from this study indicated that astrocyte-targeting strategy (AST) clearly protected neurons from MPTP neurotoxin in both the young and aged groups, while the effect of AST was less pronounced in older mice, since it could not prevent the decrease in tyrosine hydroxylase (TH) in the nigrostriatal pathway (Wang et al., 2020)

In order to expand the idea to the other solid tumors, it is also suggested to evaluate the miR-223/FOXO3a axis in other cancers and broaden the idea