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Oral formulations have been investigated for their potential effects on the stomach, intestines, and gastrointestinal lining while also being evaluated for broader systemic activity

Although the importance of these results should not be overlooked, it should be emphasized that these effects were examined in a microglial cell line and need to be further validated in whole animals

These include approved prescription weight-loss medications based on synthetic peptides that mimic natural hormones, such as semaglutide and tirzepatide, found in weight loss drugs such as Wegovy and Mounjaro respectively

The maintenance of body water balance therefore depends on different physiological processes: the renal regulation, thirst and drinking behavior, but also sweating