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(A, B) Clusters of differentially accessible regions identified in Figure 1A were queried for (A) H3K27ac and (B) H3K4me1 ChIP-seq signal in human monocytes after 0h, 1h, 4h, and 24h of BDG exposure

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The cells were seeded in 96-well plates at a density of 5 10 4 cells/well and incubated with varying concentrations (100, 1000, and 10,000 M) of the compounds for 2, 4, and 6 h