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During this stage, E2 and progesterone levels fluctuate along individualized trajectories, profoundly affecting CNS function and mood regulation pathways (134)

expected to decrease as healing progresses ESR (erythrocyte sedimentation rate) another inflammation indicator Calprotectin (fecal) specific to intestinal inflammation

3.6 Leaky gut Disruption of intestinal barrier integrity, commonly referred to as leaky gut has emerged as a key pathogenic factor in a wide range of chronic inflammatory and autoimmune diseases (Hollander and Kaunitz, 2020)

However, clinical trial data specifically on tirzepatide + B12 are not available, and individual responses vary by individual