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At its core, the innate immune systemthat is, cells such as monocytes, macrophages, dendritic cells, and neutrophilesplays a pivotal role in mounting inflammatory responses triggered by microbial or non-microbial stimuli (38)

This picture is from "Minimally Invasive Percutaneous Collagen Induction" by Desmond Fernandes - co-inventor of the Dermaroller - and it shows that creams put on the skin after dermarolling penetrate the papillary dermis