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Description

The low pH environment that AHAs require differs from the optimal range for peptide stability

In the Phase 2 Lancet trial, orforglipron 45 mg reduced HbA1c by up to 2.1 percentage points at 26 weeks, exceeding the reduction achieved by dulaglutide 1.5 mg (the active comparator)

Lu S, Ke S, Wang C, Xu Y, Li Z, Song K, Bai M, Zhou M, Yu H, Yin B (2022) NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis