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Many studies have reported imbalanced gut microbiota in patients with Sjgrens syndrome compared to controls [70, 71], and people with DED without autoimmune aetiology have shown changes in gut microbiome composition intermediate between Sjgrens syndrome and controls [71]

The World Health Organization (WHO) suggests that by 2020 the number of blind people will reach 90 million globally (Khairallah et al., 2015

10.1111/bcpt.13779 Summary Keywords metformin, genomics, metabolomics, microbiomics, precision medicine Citation Anwardeen NR, Naja K and Elrayess MA (2024) Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes

In this proposed rule, to ensure budget neutrality for the proposed update to the MS-LTC-DRG classifications and relative weights prior to the application of the 10-percent cap (that is, uncapped relative weights), under 412.517(b), we are proposing to continue to use our established two-step budget neutrality methodology