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In conclusion, PCs can alleviate diabetes-induced myocardial hypertrophy, cardiac fibrosis, and heart failure, demonstrating potential cardioprotective effects by regulating the S100A11/RAGE/PPAR signaling pathway, improving mitochondrial function, reducing oxidative stress, and inhibiting the formation of AGEs

These findings highlight the research interest of GHK-Cu in pain-related studies, opening a potential avenue for developing safer pain relief approaches

IR780-loaded MSNs nanoparticles can accumulate in tumors, destroy mitochondria and inhibit cellular respiration by decomposing H 2 O 2 , resulting in sustained reduction of hypoxia in tumor tissues, thereby enhancing the therapeutic effect of PDT (204)

Although IL-6 is known to induce hepatic hepcidin expression via the JAK2/STAT3 pathway under systemic inflammatory conditions, current evidence does not support a significant increase in hepcidin expression within chondrocytes or synovial cells in OA (40)