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In an effort to evaluate the signaling mechanism responsible for the observed cardioprotection, they demonstrated that exogenous H 2 S ameliorated myocardial ischemia-reperfusion injury in db/db diabetic mice by activating Nrf2 signaling in an ERK1/2-dependent manner (Peake et al., 2013)

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Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility

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