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Similar results have been found in vivo , doses of 4 g/kg body weight of bisphenol-A enhanced the number of BrdU + cells in the rat hippocampus, whereas doses of 40 and 400 g/kg significantly reduce them (Tiwari et al., 2015b)

Phase II conjugation reactions which generally act follow phase I activation consists of reactions in which metabolites containing appropriate functional groups are conjugated with substances such as glucuronate, glutamate, sulfate, reduced glutathione or uridine diphosphate (UDP)-glucuronic acid to finally discharge them through urine or bile

Clinicians and patients may also consider combining both systemic and intratympanic therapies to harness their complementary actions on the immune system

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