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It is important to note that mitochondrial composition in tumors is highly heterogeneous, and both metabolic demands and genetic backgrounds differ markedly from those observed in inherited mitochondrial disorders

It neutralizes reactive oxygen species (free radicals) and helps protect cells from oxidative stress, which can damage DNA, proteins, and cellular membranes

Kynurenines and depression in other neurobiological conditions Alterations in KYN metabolism extend beyond MDD and have been implicated in a range of neurobiological conditions associated with depressive symptoms, such as bipolar disorder, schizophrenia, Alzheimers disease, and acquired brain injury

2.4 The ferroptosis-inflammation vicious cycle drives chronic periodontitis Growing evidence indicates that ferroptosis can trigger inflammatory responses, while the inflammatory microenvironment further promotes ferroptosis, forming a self-amplifying vicious cycle that drives the persistent progression of chronic periodontitis