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It may be that there is an overlying cause of both CVS and migraines, and some children escape the second syndrome

doi: 10.1016/j.amepre.2022.01.012

doi: 10.1016/j.ijcard.2014.11.034 151 QuinCEstakiMVollmanDMBarnettJAGillSKGibsonDL

Similarly to our observations, the positive effect of SHBG toward PCG1 has already been reported in a previous study of Saez-Lopez and collaborators [59], who demonstrated that human SHBG transgenic mice, expressing high SHBG levels were characterized by increased expression levels of PCG1 at both mRNA and protein levels, underlying the ability of SHBG to restore PPAR effects by activating the transcription of its genes targets including mitochondrial PCG1