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[63] explored the influence of the stapled strategy on the bioactivity and proteolytic stability of hymenochirin-1B and found that certain analogs have increased protease resistance relative to the liner peptide

Accordingly, the unique genomic map of SARS-CoV-2 virus and the extent of its mediated virushost proteinprotein interactions that trigger human metabolic reprogramming and dysregulation (HMRD) in favor of the virus life cycle, defines the ultimate severity and fate of COVID-19 23,24,25,26

10.1016/j.toxlet.2014.04.011 54 LiS.TanH.-Y.WangN.ZhangZ.-J.LaoL.WongC.-W.et al (2015)

This uncertainty creates a precautionary gap- both regulators and manufacturers may be cautious, delaying product approvals until more safety data are available