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Excessive Vitamin B12 May Increase the Risk of Lung and Colon Cancer A large-scale 2017 study published in the Journal of Clinical Oncology found that males who supplemented with megadoses of vitamins B6 and B12 had a 30% to 40% increased risk of lung cancer compared to individuals who did not supplement

30 Intermittent hypoxia is thought to cause endothelial damage, inflammation, and metabolic dysfunction, which contribute to an increased risk for CVD

Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD et al (2010)