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The activity of TyrBm in the presence of L-dopa and HQ was 8% higher than with L-dopa alone for oxygen consumption measurements, and 17% higher as determined by absorbance readings

dHTC3 is a BD1-specific BRD4 degrader To further probe the mechanism of ternary complex formation, we tested whether dHTC3 activity could be blocked by iBET-BD1 or iBET-BD2, bromodomain inhibitors that selectively bind to the first or second bromodomain (BD1 or BD2) of BET proteins, respectively 71