In a study investigating the effect of MSM on acetaminophen-induced hepatotoxicity in rats, it was reported that MDA levels decreased in the MSM-treated group compared with the untreated group [32]
G., ed) Appleton-Lange, 1998, pp 50-61 Basis for individual to individual variation in drug responses Response Variation Secondary to Pharmacokinetic Differences Bioavailability Renal function Liver function Cardiac function Patient Age Response Variation Secondary to Pharmacodynamic Differences Enzyme activity Genetic differences Response Variation Secondary to Drug Interactions Stoelting, R.K., "Pharmacokinetics and Pharmacodynamics of Injected and Inhaled Drugs", in Pharmacology and Physiology in Anesthetic Practice, Lippincott-Raven Publishers, 1999, 1-17
If someone with a known B12 deficiency develops persistent anemia, elevated white blood cell (WBC) counts, or noticeable lymph node enlargement, it is important to consider the possibility of an underlying hematologic malignancy and seek prompt medical evaluation
However, the obviously lower specificity of this model might result in a higher potential for irrelevant, positive outcomes and overprediction of NA mutagenicity
