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Astrocytes are essential regulators of BBB function through their end-feet, which encase the vasculature and maintain endothelial tight junctions and ion homeostasis ( FIGURE 2 Astrocyte phenotypes and functional diversity Which astrocyte phenotypes or reactive states drive barrier loss remains unresolved

Acknowledgements The authors express profound gratitude to all the diabetic patients and non-diabetic subjects who consented and participated in the clinical experiment

This improvement in solubility and stability of LAAM GSH-CQDs can be attributed to their chemical structure, which includes ~22 amino acid groups with steric chain structures at the edges of each CQD, compared to only 8 -amino acid groups in LAAM TC-CQDs

The inclusion of broken cell wall Chlorella in the formula is a specific design choice to enhance bioavailability