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Although it is plausible that select peptides may enter formal clinical trials under an IND or through fast-track orphan designation pathways, this measured approach allows innovation to move forward without compromising ethics, compliance, or patient safety

Genetic knockout (KO) of Rac1 in excitatory neurons in mice resulted in decreased spine and synapse numbers accompanied by increased postsynaptic density (PSD) (Haditsch et al., 2009)

A Gatan K3 direct electron camera operating in correlated double sampling (CDS) mode equipped post a Gatan Quantum energy filter (Gatan, Pleasanton, CA, USA) was to record movies with a total dose of ~60 e per 2

doi: 10.3390/pharmaceutics14102014 [DOI] [PMC free article] [PubMed] [Google Scholar] 73.Bhargava A, Osusky M, Hancock RE, Forward BS, Kay WW, Misra S