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doi: 10.1111/j.1365-2559.2010.03733.x 5 NgKTYeungOWLamYFLiuJLiuHPangLet al

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The molecular mechanisms that promote the deleterious effects of alcohol metabolism to cause ARLD are intricate and multifactorial and include disruption of lipid and methionine metabolism, alterations in mitochondrial dynamics, respiration, membrane structure, mtDNA oxidation, and ROS production [69], whose final impact in ARLD onset is determined by genetic and environmental factors