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A 2019 meta-analysis by Wei et al 11 reviewed the results of 4 RCTs on the use of onabotulinumtoxinA for TN and noted a significant improvement in reported pain values in comparison with placebo, with an estimated number needed to treat of 1.9 to achieve a 50% reduction in pain intensity

Similar content being viewed by others Introduction Non-motor symptoms, including REM-sleep behavior disorders (RBD), insomnia, autonomic failure, and sometimes pain, may precede the development of Parkinsons disease (PD) motor symptoms by years and their recognition often contributes to an early identification of affected PD individuals [19, 67]

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