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However, standard IBS treatments are being applied, including dietary interventions, medications tailored to predominant symptoms (e.g., anti-diarrheals or laxatives), and psychological therapies such as cognitive behavioral therapy or gut-directed hypnotherapy

Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)

Lancet 381(9871): 102936 pmid:23352552 9

& Parkes, D