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Ang II is a potent vasoconstrictor and also stimulates Ald ( It is also noteworthy that adrenocortical glomerulosa cells are extremely sensitive to dissolved O 2 blood levels ( 2 -Hb dissociation curve to the right, lowering the affinity of Hb to O 2 , further contributing to ROS production ( Clinical Pearls An increased Ald level is a specific biomarker of the SARS-CoV-2 infection