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Building upon these findings, a subsequent Phase III study (NCT04571164) was conducted to further evaluate the tolerability, safety, and pharmacokinetics of LY03003 in a larger cohort of PD patients, aiming to optimize dosing regimens and confirm its potential as a long-acting therapeutic option 143

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2.2 Intervention in the PI3K/AKT and its associated signaling pathways The phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway is a well-established biological process involving the regulation of diverse signalings such as apoptosis, metabolism, cell proliferation and growth, protein synthesis, transcription, glucose uptake, and aerobic glycolysis in cancer cells ( 2.2.1 Inhibition of the PI3K/AKT signaling pathway Most listed active constituents address the functions to suppress the PI3K/AKT signaling pathway