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Chemistry and biological activities of flavonoids: an overview

For example, depending on the type of ROS involved, HIF-1 may or may not be required for ROS-mediated lifespan extension (Lee et al, 2010

Although these studies do not specifically differentiate between neuronal and astrocytic contributions, it is possible that the modulation of astrocytic A 1 and A 2A receptors may have an impact on the onset and progression of ALS, given the well-established importance of astrocytes in the disease [435]

For example, the quality of these studies is somewhat lower than the quality of studies of other medical interventions in Alzheimers disease and other dementia-related conditions