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Any defect in the components of UPP or a lack of their activity result in accumulation of -synuclein protein and subsequent aggregation leading in turn to the formation of Lewy bodies

To view or add a comment, sign in Proud to share my new publication Our recent research, published in International Journal of Molecular Sciences (MDPI), is now available online: "Alogliptin Mitigates Methotrexate-Induced Nephrotoxicity in a Rat Model: Antagonizing Oxidative Stress, Inflammation and Apoptosis" This study highlights the potential protective role of Alogliptin, a DPP-4 inhibitor, against Methotrexate-induced renal injury

RM was supported by FAPERJ (Grant Numbers E-26/202.668/2018, E-26/010.002215/2019, 426342/2018-6, and 312157/2016-9) and INCT-INNT (National Institute for Translational Neuroscience)

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