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How does AOD 9604 work (mechanism of action) While full mechanistic clarity is still under investigation, here are the main proposed/examined pathways: It stimulates lipolysis (the breakdown of stored triglycerides into glycerol + free fatty acids) in fat cells (adipocytes)

Studies on topical drug delivery with microneedling have shown up to 20-fold improvements in penetration for some molecules, though the exact enhancement for AHK-Cu specifically hasn't been quantified in published research