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BAs can directly inhibit IL-17A production and block CCL20-mediated transport to ameliorate psoriasiform dermatitis with minimal toxicity ( Supplementary Figure 1 ), therefore, we hypothesized that Escherichia-Shigella may exert pathogenic effects by affecting the BAs metabolic pathway

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Taken together, our data have established a causative link between OS induced aldehyde generation and the decrease in oocyte quality seen in the aged oocyte

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