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This higher antibody titer may be attributed to higher dietary Se that is reported to have role in alteration of B-cell development, diversion of Th1/Th2 balance towards Th2, 7,9,23 , ability to reduce oxidative stress, enhancement of antioxidant defenses, and promotion of anti-inflammatory cytokine production 24,55

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The hormone hepcidin, elevated in chronic inflammation, binds to ferroportin inducing its internalization and degradation, thereby trapping iron within cells such as macrophages and potentiating pro-ferroptotic microenvironments ( In summary, ferroptosis is profoundly influenced by iron regulatory mechanisms centered on IRP/IRE signaling and ferritinophagy

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