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Description

When mTOR is inhibited, the mTOR-mediated phosphorylation of an autophagy protein ATG13 will also be inhibited

Aranbewela L, Silva R

J.ChambersK

Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222