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5.4 Biomarker-guided treatment In the precision treatment strategy for gemcitabine resistance, biomarker guided treatment based on dynamic monitoring of RRM2 copy number based on ctDNA and multi-omics prediction models (such as the EXPLOR trial) provides a new paradigm for individualized intervention: Gemcitabine resistance, RRM2 gene copy number amplification drives resistance by accelerating deoxyribonucleotide triphosphate (dNTP) synthesis and enhancing DNA repair, while ctDNA-based liquid biopsy technology (such as ddPCR/NGS) can dynamically monitor the level of RRM2 amplification and track the evolution of resistant clones in real time

Recent developments in research techniques, such as single-cell RNA-sequencing, have accurately dissected gene expression changes following NMDAR-induced injuries in the mouse retina, clarifying the role of microglia in regulating inflammatory cytokines [60]

An investigation at the University of Murcia involved students from the Sport Science Department (170.83.6 cm height

Lately, glutathione injections have gained much attention with benefits that include skin lightening, detoxification, and health enhancement